I doubt you need anyone to tell you how complicated the body is—from proteins and DNA to bacteria in your gut and neurons in your brain, we are an incredibly complex system relying simultaneously on many distinct organisms. Given this complexity, it’s easy to understand why finding the underlying mechanisms of aging and trying to find solutions to it take time and a lot of research.

That being said, we are always making progress. One enzyme that seems to be essential to the aging process is AMPK, or adenosine monophosphate-activated protein kinase. When our levels of AMPK drop, researchers have discovered, our systems subsequently start to decline. The Life Extension Blog has more:

AMPK determines our body fat composition and influences how long we live. AMPK also keeps cells revitalized by promoting autophagy, a process in which damaged DNA and misshapen proteins that lead to cancer and other degenerative disease are eliminated.

Another important mechanism of AMPK is that it inhibits NF-kB, the orchestrator of inflammation. Since inflammation is the common denominator in all age-related diseases, this mechanism is crucial for guarding against the development of conditions such as cardiovascular disease, Alzheimer’s disease, cancer, etc.

If we are to lengthen our lives by a meaningful degree, it’s clear we must place some focus on AMPK. Plenty of research has already been done, thankfully, much of which you can read about in the full article.

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